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Mediation model for the association between CRP and anhedonia at 6-month follow-up, with neural response to reward outcome > neutral outcome as mediator. Age, biological sex, and BMI percentile were included as covariates. A single model was computed which included all 3 clusters associated with task effects for this contrast as mediators (rACC/mPFC, right VS, left Caudate Head). CRP: C-reactive protein. CES-D: Center for Epidemiologic Studies- Depression Scale. BMI: Body Mass Index. rACC: rostral Anterior Cingulate Cortex. mPFC: medial Prefrontal Cortex.

Journal: Brain, Behavior, & Immunity - Health

Article Title: Neural response to reward as a potential pathway from inflammation to anhedonia in adolescents at risk for depression

doi: 10.1016/j.bbih.2026.101246

Figure Lengend Snippet: Mediation model for the association between CRP and anhedonia at 6-month follow-up, with neural response to reward outcome > neutral outcome as mediator. Age, biological sex, and BMI percentile were included as covariates. A single model was computed which included all 3 clusters associated with task effects for this contrast as mediators (rACC/mPFC, right VS, left Caudate Head). CRP: C-reactive protein. CES-D: Center for Epidemiologic Studies- Depression Scale. BMI: Body Mass Index. rACC: rostral Anterior Cingulate Cortex. mPFC: medial Prefrontal Cortex.

Article Snippet: C-Reactive Protein (hsCRP) ELISA from ALPCO was used to measure CRP.

Techniques: